The Pininfarina-designed spider version of the 275 GTB shared the same independent rear suspension and rear-mounted gearbox. The V12 once again was fitted with wet sump lubrication, but the engine developed around 20 bhp less; given the type of car and its target clientele, torque and flexibility were favoured over maximum power.

While the 275 GTB wore alloy rims, the GTS was fitted with wire wheels, creating a more elegant look.

The mechanical layout was very similar to the berlinetta model, but the Pininfarina body clothing it was completely different. Also whilst the Pininfarina designed berlinetta body was constructed at the Scaglietti in Modena, that of the spider was constructed at the Pininfarina works in Turin, before being delivered fully trimmed to the Ferrari factory for fitment of the mechanical components.

The bodies were mounted on the same 2400mm wheelbase chassis as the 275 GTB with factory reference numbers 563, all were numbered in the odd chassis number road car sequence, and as with the 275 GTB, it were available in right or left hand drive form. The standard wheels were Borrani wire wheels throughout the production period.

The engine was the same as that fitted to the 275 GTB, a single overhead camshaft per bank V12 unit, with factory type reference 213, of 3286cc capacity, with a bore and stroke of 77mm x 58.8mm. It was fitted with a bank of either three twin choke Weber 40 DCZ/6 or 40 DFI/1 carburettors, with a twin coil and rear of engine mounted distributor ignition system, to produce a claimed 260 bhp, some 20 bhp below that claimed for the berlinetta, confirming that this model was more restrained than its berlinetta peer.

Similarly it shared the same transmission and suspension layout as the berlinetta, a five speed transaxle and four wheel independent suspension, although it never received the final rigid torque tube transmission arrangement.

The production period ran from late 1964 through to early 1966, in the chassis number range 06315 to 08653.